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Article

A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus for Tunisian Adults after Renal Transplantation.

Therapeutic drug monitoring - 1 Feb 2024

Abderahmene Amani, Francke Marith I, Andrews Louise M, Hesselink Dennis A, Amor Dorra, Sahtout Wissal, Ajmi Marwa, Mastouri Hayfa, Bouslama Ali, Zellama Dorsaf, Omezzine Asma, De Winter Brenda C M

Abstract excerpt

BACKGROUND: Tacrolimus is the most frequently used immunosuppressive drug for preventing renal rejection. However, its use is hampered by its narrow therapeutic index and large intra and interpatient variability in pharmacokinetics. The objective of this study was to externally validate a tacrolimus population pharmacokinetic model developed for the Dutch population and adjust the model for the Tunisian...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38018879
DOI: 10.1097/FTD.0000000000001147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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