Article
Population pharmacokinetic modelling and design of a Bayesian estimator for therapeutic drug monitoring of tacrolimus in lung transplantation.
Clinical pharmacokinetics - 1 Mar 2012
Monchaud Caroline, de Winter Brenda C, Knoop Christiane, Estenne Marc, Reynaud-Gaubert Martine, Pison Christophe, Stern Marc, Kessler Romain, Guillemain Romain, Marquet Pierre, Rousseau Annick
Abstract excerpt
BACKGROUND: Therapeutic drug monitoring of tacrolimus is a major support to patient management and could help improve the outcome of lung transplant recipients, by minimizing the risk of rejections and infections. However, despite the wide use of tacrolimus as part of maintenance immunosuppressive regimens after lung transplantation, little is known about its pharmacokinetics in this population. Better knowledge...
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