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Article

Evaluating tacrolimus pharmacokinetic models in adult renal transplant recipients with different CYP3A5 genotypes.

European journal of clinical pharmacology - 1 Nov 2018

Hu Can, Yin Wen-Jun, Li Dai-Yang, Ding Jun-Jie, Zhou Ling-Yun, Wang Jiang-Lin, Ma Rong-Rong, Liu Kun, Zhou Ge, Zuo Xiao-Cong

Abstract excerpt

PURPOSE: Numerous studies have been conducted on the population pharmacokinetics of tacrolimus in adult renal transplant recipients. It has been reported that the cytochrome P450 (CYP) 3A5 genotype is an important cause of variability in tacrolimus pharmacokinetics. However, the predictive performance of population pharmacokinetic (PK) models of tacrolimus should be evaluated prior to their implementation in...

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Identifiers

PMID: 30019212
DOI: 10.1007/s00228-018-2521-6

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