Article
Tacrolimus population pharmacokinetic-pharmacogenetic analysis and Bayesian estimation in renal transplant recipients.
Clinical pharmacokinetics - 1 Jan 2009
Benkali Khaled, Prémaud Aurelie, Picard Nicolas, Rérolle Jean-Philippe, Toupance Olivier, Hoizey Guillaume, Turcant Alain, Villemain Florence, Le Meur Yannick, Marquet Pierre, Rousseau Annick
Abstract excerpt
OBJECTIVES: The aims of this study were (i) to investigate the population pharmacokinetics of tacrolimus in renal transplant recipients, including the influence of biological and pharmacogenetic covariates; and (ii) to develop a Bayesian estimator able to reliably estimate the individual pharmaco...
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