Article
A prospective controlled, randomized clinical trial of kidney transplant recipients developed personalized tacrolimus dosing using model-based Bayesian Prediction.
Kidney international - 1 Oct 2023
Lloberas Nuria, Grinyó Josep M, Colom Helena, Vidal-Alabró Anna, Fontova Pere, Rigo-Bonnin Raul, Padró Ariadna, Bestard Oriol, Melilli Edoardo, Montero Nuria, Coloma Ana, Manonelles Anna, Meneghini Maria, Favà Alex, Torras Joan, Cruzado Josep M
Abstract excerpt
For three decades, tacrolimus (Tac) dose adjustment in clinical practice has been calculated empirically according to the manufacturer's labeling based on a patient's body weight. Here, we developed and validated a Population pharmacokinetic (PPK) model including pharmacogenetics (cluster CYP3A4/CYP3A5), age, and hematocrit. Our study aimed to assess the clinical applicability of this PPK model in the achievement...
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