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Article

Prediction of the tacrolimus population pharmacokinetic parameters according to CYP3A5 genotype and clinical factors using NONMEM in adult kidney transplant recipients.

European journal of clinical pharmacology - 1 Jan 2013

Han Nayoung, Yun Hwi-yeol, Hong Jin-yi, Kim In-Wha, Ji Eunhee, Hong Su Hyun, Kim Yon Su, Ha Jongwon, Shin Wan Gyoon, Oh Jung Mi

Abstract excerpt

PURPOSE: Tacrolimus is a commonly used immunosuppressant in solid organ transplantation recipients, but it is characterized by a narrow therapeutic range and large inter-individual variability. The purpose of this study was to establish a population pharmacokinetic (PK) model of tacrolimus and evaluate the influence of clinical covariates, including the genetic polymorphisms of the cytochrome P450 3A5 gene...

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Source

Identifiers

PMID: 22660440
DOI: 10.1007/s00228-012-1296-4

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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