Article
A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation.
Clinical pharmacokinetics - 1 Apr 2018
Andrews Louise M, Hesselink Dennis A, van Gelder Teun, Koch Birgit C P, Cornelissen Elisabeth A M, Brüggemann Roger J M, van Schaik Ron H N, de Wildt Saskia N, Cransberg Karlien, de Winter Brenda C M
Abstract excerpt
BACKGROUND: Multiple clinical, demographic, and genetic factors affect the pharmacokinetics of tacrolimus in children, yet in daily practice, a uniform body-weight based starting dose is used. It can take weeks to reach the target tacrolimus pre-dose concentration. OBJECTIVES: The objectives of this study were to determine the pharmacokinetics of tacrolimus immediately after kidney transplantation and to find...
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