Article
Inclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation.
Transplant international : official journal of the European Society for Organ Transplantation - 1 Dec 2013
Åsberg Anders, Midtvedt Karsten, van Guilder Mike, Størset Elisabet, Bremer Sara, Bergan Stein, Jelliffe Roger, Hartmann Anders, Neely Michael N
Abstract excerpt
Following organ engraftment, initial dosing of tacrolimus is based on recipient weight and adjusted by measured C(0) concentrations. The bioavailability and elimination of tacrolimus are affected by the patients CYP3A5 genotype. Prospective data of the clinical advantage of knowing patient's CYP3A5 genotype prior to transplantation are lacking. A nonparametric population model was developed for tacrolimus in...
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