Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of filaggrin variants with asthma and rhinitis: is eczema or allergic sensitization status an effect modifier?

International archives of allergy and immunology - 1 Jan 2014

Ziyab Ali H, Karmaus Wilfried, Zhang Hongmei, Holloway John W, Steck Susan E, Ewart Susan, Arshad Syed Hasan

Abstract excerpt

BACKGROUND: Associations of variants of the filaggrin gene, i.e. FLG with asthma and rhinitis have been shown to be modulated by eczema status. However, it is unknown whether allergic sensitization status modifies this association. The aim of this study was to determine whether FLG variants need eczema and/or allergic sensitization as a necessary component to execute adverse effects on coexisting and subsequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Eczema

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Filaggrin Proteins

Share to Genotyping Techniques

Share to Hypersensitivity, Immediate

Share to Intermediate Filament Proteins

Share to Rhinitis

Share to Skin Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 25277085
DOI: 10.1159/000365990
PMCID: PMC4281035

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of filaggrin variants with asthma and rhinitis: is eczema or allergic sensitization status an effect modifier?PMID 25277085Read ↗

Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort.Semantic proximity Read ↗

Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization.Semantic proximity Read ↗

Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.Semantic proximity Read ↗

Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth.Semantic proximity Read ↗

Epistasis between FLG and IL4R Genes on the Risk of Allergic Sensitization: Results from Two Population-Based Birth Cohort Studies.Semantic proximity Read ↗

Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis.Semantic proximity Read ↗

Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children.Semantic proximity Read ↗

The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.Semantic proximity Read ↗

Filaggrin mutations, atopic eczema, hay fever, and asthma in children.Semantic proximity Read ↗

An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma.Semantic proximity Read ↗

Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease.Semantic proximity Read ↗

Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.