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Article

Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.

PloS one - 1 Jan 2012

Ziyab Ali H, Karmaus Wilfried, Yousefi Mitra, Ewart Susan, Schauberger Eric, Holloway John W, Zhang Hongmei, Arshad Syed Hasan

Abstract excerpt

BACKGROUND: Immune specific genes as well as genes regulating the formation of skin barrier are major determinants for eczema manifestation. There is a debate as to whether allergic sensitization and filaggrin gene (FLG) variants lead to eczema or FLG variants and eczema increase the risk of allergic sensitization. To investigate the time-order between eczema and allergic sensitization with respect to FLG...

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Source

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Identifiers

PMID: 22403702
DOI: 10.1371/journal.pone.0032721
PMCID: PMC3293849

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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