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Article

Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 2018

Chan Adrian, Terry William, Zhang Hongmei, Karmaus Wilfried, Ewart Susan, Holloway John W, Roberts Graham, Kurukulaaratchy Ramesh, Arshad Syed Hasan

Abstract excerpt

BACKGROUND: Filaggrin loss-of-function (FLG-LOF) mutations are an established genetic cause of eczema. These mutations have subsequently been reported to increase the risk of aeroallergen sensitization and allergic airway disease. However, it is unclear whether FLG variants require both eczema and aeroallergen sensitization to influence airway disease development long-term outcomes. OBJECTIVE: To examine the...

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Identifiers

PMID: 29266469
DOI: 10.1111/cea.13077
PMCID: PMC5790610

Genes

FLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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