Article
Filaggrin mutations, atopic eczema, hay fever, and asthma in children.
The Journal of allergy and clinical immunology - 1 May 2008
Weidinger Stephan, O'Sullivan Maureen, Illig Thomas, Baurecht Hansjörg, Depner Martin, Rodriguez Elke, Ruether Andreas, Klopp Norman, Vogelberg Christian, Weiland Stephan K, McLean W H Irwin, von Mutius Erika, Irvine Alan D, Kabesch Michael
Abstract excerpt
BACKGROUND: Mutations in the filaggrin gene (FLG) have been shown to play a significant role in ichthyosis vulgaris and eczema, 2 common chronic skin diseases. However, their role in the development of other atopic diseases such as asthma and rhinitis has not yet been clarified in large population-based studies. OBJECTIVES: To study the effect of FLG mutations at the population level and their effect on other...
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