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Article

Epistasis between FLG and IL4R Genes on the Risk of Allergic Sensitization: Results from Two Population-Based Birth Cohort Studies.

Scientific reports - 19 Feb 2018

Ziyab Ali H, Hankinson Jenny, Ewart Susan, Schauberger Eric, Kopec-Harding Kamilla, Zhang Hongmei, Custovic Adnan, Arshad Hasan, Simpson Angela, Karmaus Wilfried J

Abstract excerpt

Immune-specific genes as well as genes responsible for the formation and integrity of the epidermal barrier have been implicated in the pathogeneses of allergic sensitization. This study sought to determine whether an epistatic effect (gene-gene interaction) between genetic variants within interleukin 4 receptor (IL4R) and filaggrin (FLG) genes predispose to the development of allergic sensitization. Data from...

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Identifiers

PMID: 29459738
DOI: 10.1038/s41598-018-21459-x
PMCID: PMC5818621

Genes

FLG

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