Article
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.
The Journal of allergy and clinical immunology - 1 Oct 2006
Marenholz Ingo, Nickel Renate, Rüschendorf Franz, Schulz Florian, Esparza-Gordillo Jorge, Kerscher Tamara, Grüber Christoph, Lau Susanne, Worm Margitta, Keil Thomas, Kurek Michael, Zaluga Elisabetha, Wahn Ulrich, Lee Young-Ae
Abstract excerpt
BACKGROUND: Childhood eczema often precedes the development of asthma and allergic rhinitis in the so-called atopic march. Recently, 2 loss-of-function mutations in the gene encoding the epidermal barrier protein filaggrin were reported to be predisposing factors for eczema and concomitant asthma, suggesting a possible role in disease transition. OBJECTIVE: We aimed to assess the importance of filaggrin...
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