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Article

Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.

Molecular biology of the cell - 1 Dec 2014

Busch David J, Oliphint Paul A, Walsh Rylie B, Banks Susan M L, Woods Wendy S, George Julia M, Morgan Jennifer R

Abstract excerpt

Parkinson's disease is associated with multiplication of the α-synuclein gene and abnormal accumulation of the protein. In animal models, α-synuclein overexpression broadly impairs synaptic vesicle trafficking. However, the exact steps of the vesicle trafficking pathway affected by excess α-synuclein and the underlying molecular mechanisms remain unknown. Therefore we acutely increased synuclein levels at a...

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Identifiers

PMID: 25273557
DOI: 10.1091/mbc.E14-02-0708
PMCID: PMC4244201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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