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Article

α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Apr 2016

Xu Jianhua, Wu Xin-Sheng, Sheng Jiansong, Zhang Zhen, Yue Hai-Yuan, Sun Lixin, Sgobio Carmelo, Lin Xian, Peng Shiyong, Jin Yinghui, Gan Lin, Cai Huaibin, Wu Ling-Gang

Abstract excerpt

α-Synuclein (α-syn) missense and multiplication mutations have been suggested to cause neurodegenerative diseases, including Parkinson's disease (PD) and dementia with Lewy bodies. Before causing the progressive neuronal loss, α-syn mutations impair exocytosis, which may contribute to eventual neurodegeneration. To understand how α-syn mutations impair exocytosis, we developed a mouse model that selectively...

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Identifiers

PMID: 27098685
DOI: 10.1523/JNEUROSCI.3627-15.2016
PMCID: PMC4837680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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