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Article

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease

9 Jun 2010

Abstract excerpt

The pre-synaptic protein alpha-synuclein is the main component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. Mutations in the alpha-synuclein gene cause familial forms of Parkinson's disease and dementia with Lewy bodies. We previously described a transgenic mouse line expressing truncated human alpha-synuclein(1-120) that...

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PMID: 20534649
DOI: 10.1093/brain/awq132

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