Article

Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses

2019-01-10

Abstract excerpt

<h4>ABSTRACT</h4> α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presynapses where the protein is normally localized. While it is generally agreed that excess α-synuclein impairs synaptic vesicle trafficking, the underlying...

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Literature Corpus work: e53d8a56-7301-589e-bed5-9c0ca0857bf5
DOI: 10.1101/517524

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