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Article

A Pathologic Cascade Leading to Synaptic Dysfunction in -Synuclein-Induced Neurodegeneration

16 Jun 2010

Abstract excerpt

Several neurodegenerative diseases are typified by intraneuronal alpha-synuclein deposits, synaptic dysfunction, and dementia. While even modest alpha-synuclein elevations can be pathologic, the precise cascade of events induced by excessive alpha-synuclein and eventually culminating in synaptotoxicity is unclear. To elucidate this, we developed a quantitative model system to evaluate evolving...

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PMID: 20554859
DOI: 10.1523/jneurosci.1091-10.2010

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