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Article

Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.

PloS one - 1 Jan 2012

Platt Nicola J, Gispert Suzana, Auburger Georg, Cragg Stephanie J

Abstract excerpt

Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD. They display progressive motor deficits, abnormal cellular accumulation of α-syn, and deficits in dopamine-dependent corticostriatal plasticity, which, in the absence of overt nigrostriatal degeneration,...

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Identifiers

PMID: 22570709
DOI: 10.1371/journal.pone.0036397
PMCID: PMC3343082

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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