Article

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration

2020-10-12

Abstract excerpt

Alpha-synuclein (α-syn) mislocalisation and accumulation in intracellular inclusions is the major pathological hallmark of degenerative synucleinopathies, including Parkinson’s disease, Parkinson’s disease with Dementia and Dementia with Lewy Bodies. Typical symptoms are behavioural abnormalities including motor deficits that mark disease progression, while non-motor symptoms and synaptic deficits are already appa...

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Literature Corpus work: 7032384e-5fec-5b2d-b2b7-ec39db8ebe9b
DOI: 10.1101/2020.10.12.335778

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