Article

Overexpression of α-Synuclein Alters The Nanoscopic Organisation of Presynaptic Proteins

2025-10-13

Abstract excerpt

Parkinson’s Disease (PD) is characterised by accumulation of α-synuclein (α-Syn), but how elevated α-Syn alters presynaptic architecture during prodromal phases of the disease remains unclear. We investigated presynaptic morphology and two key presynaptic proteins: MYCBP2; and the Active Zone (AZ) protein ELKS. Primary rat cortical neurons were transfected with wildtype α-Syn, or the familial A30P mutant, and nano...

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Literature Corpus work: 778cd73c-f1e0-56b7-9d03-5839a3d4b9fb
DOI: 10.1101/2025.10.10.681706

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