Article

Regulation of Exocytosis and Mitochondrial Relocalization by Alpha-Synuclein in a Mammalian Cell Model

2018-12-10

Abstract excerpt

<h4>ABSTRACT</h4> We characterized phenotypes in RBL-2H3 mast cells transfected with human alpha synuclein (a-syn) using stimulated exocytosis of recycling endosomes as a proxy for similar activities of synaptic vesicles in neurons. We found that low expression of a-syn inhibits stimulated exocytosis and that higher expression causes slight enhancement. NMR measurements of membrane interactions correlate with the...

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Literature Corpus work: 02814ba5-741b-588d-95c9-4a445edd5a9a
DOI: 10.1101/492066

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