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Article

Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Jun 2017

Eguchi Kohgaku, Taoufiq Zacharie, Thorn-Seshold Oliver, Trauner Dirk, Hasegawa Masato, Takahashi Tomoyuki

Abstract excerpt

α-Synuclein is a presynaptic protein the function of which has yet to be identified, but its neuronal content increases in patients of synucleinopathies including Parkinson's disease. Chronic overexpression of α-synuclein reportedly expresses various phenotypes of synaptic dysfunction, but the primary target of its toxicity has not been determined. To investigate this, we acutely loaded human recombinant...

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Identifiers

PMID: 28576942
DOI: 10.1523/JNEUROSCI.0179-17.2017
PMCID: PMC6596501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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