Article

Glutamatergic synaptic resilience to overexpressed human alpha-synuclein

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Alpha synuclein (aSyn) is an abundant protein that, in the brain, is concentrated in neuronal presynaptic boutons and associates with synaptic vesicles. aSyn is strongly linked with Parkinson’s disease (PD) due to its accumulation in pathognomonic inclusions in neuronal cells, including in glutamatergic neurons. While increased expression of wild-type (WT) aSyn due to multiplications of the SNCA...

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Literature Corpus work: a441c663-ad5f-5ddc-8a85-800a73f9ae67
DOI: 10.1101/2025.02.06.636960

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