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High frequency electrical stimulation reduces α-synuclein levels and α-synuclein-mediated autophagy dysfunction

12 Jul 2024

Abstract excerpt

Accumulation of α-synuclein (α-Syn) has been implicated in proteasome and autophagy dysfunction in Parkinson's disease (PD). High frequency electrical stimulation (HFS) mimicking clinical parameters used for deep brain stimulation (DBS) in vitro or DBS in vivo in preclinical models of PD have been found to reduce levels of α-Syn and, in certain cases, provide possible neuroprotection. However, the mechanisms by...

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PMID: 38997273
DOI: 10.1038/s41598-024-64131-3

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