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Article

HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse.

Nucleic acids research - 29 Oct 2014

Ichiyanagi Tomoko, Ichiyanagi Kenji, Ogawa Ayako, Kuramochi-Miyagawa Satomi, Nakano Toru, Chuma Shinichiro, Sasaki Hiroyuki, Udono Heiichiro

Abstract excerpt

HSP90, found in all kingdoms of life, is a major chaperone protein regulating many client proteins. We demonstrated that HSP90α, one of two paralogs duplicated in vertebrates, plays an important role in the biogenesis of fetal PIWI-interacting RNAs (piRNA), which act against the transposon activities, in mouse male germ cells. The knockout mutation of Hsp90α resulted in a large reduction in the expression of...

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Identifiers

PMID: 25262350
DOI: 10.1093/nar/gku881
PMCID: PMC4231750

Genes

FKBP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse.PMID 25262350Read ↗

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