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Article

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.

PLoS genetics - 1 Feb 2021

Guan Yongjuan, Keeney Scott, Jain Devanshi, Wang P Jeremy

Abstract excerpt

Piwi-interacting RNAs (piRNAs) play critical roles in protecting germline genome integrity and promoting normal spermiogenic differentiation. In mammals, there are two populations of piRNAs: pre-pachytene and pachytene. Transposon-rich pre-pachytene piRNAs are expressed in fetal and perinatal germ cells and are required for retrotransposon silencing, whereas transposon-poor pachytene piRNAs are expressed in...

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Identifiers

PMID: 33635934
DOI: 10.1371/journal.pgen.1009265
PMCID: PMC7946307

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yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.PMID 33635934Read ↗

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