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Article

Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.

Scientific reports - 25 Jun 2018

Ungewitter Erica K, Rotgers Emmi, Kang Hong Soon, Lichti-Kaiser Kristin, Li Leping, Grimm Sara A, Jetten Anton M, Yao Humphrey H-C

Abstract excerpt

Fetal germ cell development is regulated by an elaborate combination of cell-extrinsic and cell-intrinsic signals. Here we identify a novel role for the Krüppel-like transcription factor Gli-Similar 3 (Glis3) in male germ cell development in the mouse embryos. Glis3 is expressed in male germ cells during the brief window of time prior to initiation of piRNA-dependent retrotransposon surveillance. Disruption of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29941866
DOI: 10.1038/s41598-018-27843-x
PMCID: PMC6018429

Genes

GLIS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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