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Article

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.

Genes & development - 1 Apr 2008

Kuramochi-Miyagawa Satomi, Watanabe Toshiaki, Gotoh Kengo, Totoki Yasushi, Toyoda Atsushi, Ikawa Masahito, Asada Noriko, Kojima Kanako, Yamaguchi Yuka, Ijiri Takashi W, Hata Kenichiro, Li En, Matsuda Yoichi, Kimura Tohru, Okabe Masaru, Sakaki Yoshiyuki, Sasaki Hiroyuki, Nakano Toru

Abstract excerpt

Silencing of transposable elements occurs during fetal gametogenesis in males via de novo DNA methylation of their regulatory regions. The loss of MILI (miwi-like) and MIWI2 (mouse piwi 2), two mouse homologs of Drosophila Piwi, activates retrotransposon gene expression by impairing DNA methylation in the regulatory regions of the retrotransposons. However, as it is unclear whether the defective DNA methylation...

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Identifiers

PMID: 18381894
DOI: 10.1101/gad.1640708
PMCID: PMC2279202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.PMID 18381894Read ↗

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