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Article

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2010

Zheng Ke, Xiol Jordi, Reuter Michael, Eckardt Sigrid, Leu N Adrian, McLaughlin K John, Stark Alexander, Sachidanandam Ravi, Pillai Ramesh S, Wang Peijing Jeremy

Abstract excerpt

Piwi-interacting RNAs (piRNAs) are essential for silencing of transposable elements in the germline, but their biogenesis is poorly understood. Here we demonstrate that MOV10L1, a germ cell-specific putative RNA helicase, is associated with Piwi proteins. Genetic disruption of the MOV10L1 RNA helicase domain in mice renders both MILI and MIWI2 devoid of piRNAs. Absence of a functional piRNA pathway in Mov10l1...

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Identifiers

PMID: 20534472
DOI: 10.1073/pnas.1003953107
PMCID: PMC2900664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.PMID 20534472Read ↗

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.Semantic proximity Read ↗

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.Semantic proximity Read ↗

<i>yama</i> , a mutant allele of <i>Mov10l1</i> , disrupts retrotransposon silencing and piRNA biogenesisSemantic proximity Read ↗

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.Semantic proximity Read ↗

PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.Semantic proximity Read ↗

Developmentally regulated piRNA clusters implicate MILI in transposon control.Semantic proximity Read ↗

Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control.Semantic proximity Read ↗

Intact piRNA pathway prevents L1 mobilization in male meiosis.Semantic proximity Read ↗

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in miceSemantic proximity Read ↗

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.Semantic proximity Read ↗

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.Semantic proximity Read ↗

Golden hamster piRNAs are necessary for early embryonic development and establishment of spermatogoniaSemantic proximity Read ↗

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