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Article

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

Genes & development - 1 Jul 2015

Wasik Kaja A, Tam Oliver H, Knott Simon R, Falciatori Ilaria, Hammell Molly, Vagin Vasily V, Hannon Gregory J

Abstract excerpt

PIWI proteins and their associated piRNAs protect germ cells from the activity of mobile genetic elements. Two classes of piRNAs—primary and secondary—are defined by their mechanisms of biogenesis. Primary piRNAs are processed directly from transcripts of piRNA cluster loci, whereas secondary piRNAs are generated in an adaptive amplification loop, termed the ping-pong cycle. In mammals, piRNA populations are...

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Identifiers

PMID: 26115953
DOI: 10.1101/gad.265215.115
PMCID: PMC4511215

Genes

RNF17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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