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Article

Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice

27 Jul 2017

Abstract excerpt

Mammalian genomes harbor millions of retrotransposon copies, some of which are transpositionally active. In mouse prospermatogonia, PIWI-interacting small RNAs (piRNAs) combat retrotransposon activity to maintain the genomic integrity. The piRNA system destroys retrotransposon-derived RNAs and guides de novo DNA methylation at some retrotransposon promoters. However, it remains unclear whether DNA methylation...

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PMID: 28749988
DOI: 10.1371/journal.pgen.1006926

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Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in micePMID 28749988Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.Semantic proximity Read ↗

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.Semantic proximity Read ↗

An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.Semantic proximity Read ↗

Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.Semantic proximity Read ↗

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.Semantic proximity Read ↗

Epigenetic factors in the regulation of prospermatogonia and spermatogonial stem cellsSemantic proximity Read ↗

Conserved enhancer association of piRNAs and the implication in germ cell fate surveillanceSemantic proximity Read ↗

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.Semantic proximity Read ↗

Pachytene piRNAs define a conserved program of meiotic gene regulationSemantic proximity Read ↗

PIWI proteins and PIWI-interacting RNAs in the soma.Semantic proximity Read ↗

<i>yama</i> , a mutant allele of <i>Mov10l1</i> , disrupts retrotransposon silencing and piRNA biogenesisSemantic proximity Read ↗

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