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Article

Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells

18 Jan 2019

Abstract excerpt

Epigenetic resetting in germ cells during development de-represses transposable elements (TEs). piRNAs protect fetal germ cells by targeted mRNA destruction and deposition of repressive epigenetic marks. Here, we provide the first evidence for an active piRNA pathway and TE repression in germ cells of human fetal testis. We identify pre-pachytene piRNAs with features of secondary amplification that map most...

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PMID: 30658985
DOI: 10.1242/dev.171157

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