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Article

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2010

Frost Robert J A, Hamra F Kent, Richardson James A, Qi Xiaoxia, Bassel-Duby Rhonda, Olson Eric N

Abstract excerpt

Piwi-interacting RNAs (piRNAs) comprise a broad class of small noncoding RNAs that function as an endogenous defense system against transposable elements. Here we show that the putative DExD-box helicase MOV10-like-1 (MOV10L1) is essential for silencing retrotransposons in the mouse male germline...

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Source

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Identifiers

PMID: 20547853
DOI: 10.1073/pnas.1007158107
PMCID: PMC2900665

Genes

HSPA2
MOV10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20547853-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.PMID 20547853Read ↗

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.Semantic proximity Read ↗

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.Semantic proximity Read ↗

<i>yama</i> , a mutant allele of <i>Mov10l1</i> , disrupts retrotransposon silencing and piRNA biogenesisSemantic proximity Read ↗

Golden hamster piRNAs are necessary for early embryonic development and establishment of spermatogoniaSemantic proximity Read ↗

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.Semantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertilitySemantic proximity Read ↗

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in miceSemantic proximity Read ↗

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in miceSemantic proximity Read ↗

PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.Semantic proximity Read ↗

Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis.Semantic proximity Read ↗

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.Semantic proximity Read ↗

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