Article
The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse.
PloS one - 31 Dec 2010
Grad Iwona, Cederroth Christopher R, Walicki Joël, Grey Corinne, Barluenga Sofia, Winssinger Nicolas, De Massy Bernard, Nef Serge, Picard Didier
Abstract excerpt
The molecular chaperone Hsp90 has been found to be essential for viability in all tested eukaryotes, from the budding yeast to Drosophila. In mammals, two genes encode the two highly similar and functionally largely redundant isoforms Hsp90α and Hsp90β. Although they are co-expressed in most if not all cells, their relative levels vary between tissues and during development. Since mouse embryos lacking Hsp90β die...
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