Article
Intact piRNA pathway prevents L1 mobilization in male meiosis.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017
Newkirk Simon J, Lee Suman, Grandi Fiorella C, Gaysinskaya Valeriya, Rosser James M, Vanden Berg Nicole, Hogarth Cathryn A, Marchetto Maria C N, Muotri Alysson R, Griswold Michael D, Ye Ping, Bortvin Alex, Gage Fred H, Boeke Jef D, An Wenfeng
Abstract excerpt
The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic defects. It remains unknown whether L1 expression simply highlights piRNA deficiency or actually drives the germ-cell demise. Specifically, the sheer abundance of genomic L1 copies prevents reliable quantification of new...
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