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Article

Co-mapping clonal and transcriptional heterogeneity in somatic evolution via GoT-Multi.

Cell genomics - 14 Jan 2026

Pak Minwoo, Saurty-Seerunghen Mirca S, Wise Kellie, Abera Tsega-Ab, Lama Chhiring, Parghi Neelang, Kang Ted, Sun Xiaotian, Gao Qi, Bao Liming, Roshal Mikhail, Allan John N, Furman Richard R, Martelotto Luciano G, Nam Anna S

Abstract excerpt

Somatic evolution leads to clonal heterogeneity, which fuels cancer progression and therapy resistance. To decipher the consequences of clonal heterogeneity, we require a method that deconvolutes complex clonal architectures and their downstream transcriptional states. We developed Genotyping of Transcriptomes for multiple targets and sample types (GoT-Multi), a high-throughput, formalin-fixed paraffin-embedded...

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Share to Clonal Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 41075791
DOI: 10.1016/j.xgen.2025.101036
PMCID: PMC12926217

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MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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