Article

Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome

2023-11-10

Abstract excerpt

Cancer development, progression, and response to treatment are evolutionary processes, but characterising the evolutionary dynamics at sufficient scale to be clinically-meaningful has remained challenging. Here, we develop a new methodology called EVOFLUx, based upon natural DNA methylation barcodes fluctuating over time, that quantitatively infers evolutionary dynamics using only a bulk tumour methylation profile...

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Literature Corpus work: 3cc14134-7273-51b4-82d6-0ee4f2c05de1
DOI: 10.1101/2023.11.10.23298336

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