Article

scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells

2022-04-12

Abstract excerpt

Single-cell DNA methylation profiling currently suffers from excessive noise and/or limited cellular throughput. We developed scTAM-seq, a targeted bisulfite-free method for profiling up to 650 CpGs in up to 10,000 cells per experiment, with a dropout rate of less than seven percent. scTAM-seq focuses sequencing coverage on informative, variably methylated CpGs that in many tissues and cell types make up a minor f...

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Literature Corpus work: 28d66ecf-5424-5327-8017-cb81c9383fb6
DOI: 10.1101/2022.04.11.487648

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