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Article

Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML.

Cancer discovery - 1 Dec 2020

Li Sheng, Chen Xiaowen, Wang Jiahui, Meydan Cem, Glass Jacob L, Shih Alan H, Delwel Ruud, Levine Ross L, Mason Christopher E, Melnick Ari M

Abstract excerpt

Epigenetic allele diversity is linked to inferior prognosis in acute myeloid leukemia (AML). However, the source of epiallele heterogeneity in AML is unknown. Herein we analyzed epiallele diversity in a genetically and clinically annotated AML cohort. Notably, AML driver mutations linked to transcription factors and favorable outcome are associated with epigenetic destabilization in a defined set of susceptible...

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Share to Acute Myeloid Leukemia Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32938585
DOI: 10.1158/2159-8290.CD-19-0897
PMCID: PMC7710625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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