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Article

Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole.

Biochemical pharmacology - 1 Dec 2014

Martínez Carmen, Andreu Inmaculada, Amo Gemma, Miranda Miguel A, Esguevillas Gara, Torres María José, Blanca-López Natalia, Blanca Miguel, García-Martín Elena, Agúndez José A G

Abstract excerpt

Metamizole is a pain-killer drug that has been banned in some countries because of its toxicity, but it is still used in many countries due to its effective analgesic and antispasmodic properties. Although large variability in the biodisposition and adverse effects of metamizole are known, factors underlying this variability are poorly understood. We analyzed the urinary recovery of metabolites, as well as the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

Share to Cytochrome P-450 CYP2C19

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Source

Identifiers

PMID: 25241292
DOI: 10.1016/j.bcp.2014.09.005

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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