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Article

Sex Differences in Associations Between CYP2D6 Phenotypes and Response to Opioid Analgesics

1 Mar 2020

Abstract excerpt

BACKGROUND: Several small studies have previously investigated associations between the cytochrome P450 2D6 (CYP2D6) metabolism and response to opioids. We used a large sample of patients to study associations between CYP2D6 phenotypes and estimated CYP2D6 enzymatic activity scores with pain control and adverse reactions related to codeine and tramadol use. We conducted additional analyses to determine whether...

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PMID: 32214840
DOI: 10.2147/pgpm.s239222

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