Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Precision Medicine in Toxicology.

Clinics in laboratory medicine - 1 Dec 2016

Schwarz Daniel A, George M P, Bluth Martin H

Abstract excerpt

Precision medicine applies primarily to pharmacokinetics in toxicology. Mastering hepatic metabolism through an understanding of the genetics behind Phase I, or oxidation/reduction and some Phase II, or conjugation, enhances the scientific and clinical application of common drug toxicology. This review includes basic hepatic metabolism, the common substrates, inducers and inhibitors of cytochrome P450 along with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme Inhibitors
Share to Cytochrome P-450 Enzyme System
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Induction

Share to Oxidation-Reduction

Share to Polymorphism, Single Nucleotide

Share to Precision Medicine

Source

Identifiers

PMID: 27842787
DOI: 10.1016/j.cll.2016.07.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Precision Medicine in Toxicology.PMID 27842787Read ↗

Pharmacogenetics and forensic toxicology.Semantic proximity Read ↗

[Toxicology and pharmacogenetics].Semantic proximity Read ↗

Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effectsSemantic proximity Read ↗

Genetic basis of toxic reactions to drugs and chemicals.Semantic proximity Read ↗

Strategies and Molecular Probes to Investigate the Role of Cytochrome P450 in Drug MetabolismSemantic proximity Read ↗

Multi-factorial pharmacokinetic interactions: unraveling complexities in precision drug therapySemantic proximity Read ↗

The biochemistry of drug metabolism--an introduction: part 6. Inter-individual factors affecting drug metabolism.Semantic proximity Read ↗

The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury.Semantic proximity Read ↗

Induction of Drug-Metabolizing Enzymes: A Path to the Discovery of Multiple Cytochromes P450Semantic proximity Read ↗

Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters.Semantic proximity Read ↗

Pharmacogenomics for the forensic toxicologist.Semantic proximity Read ↗

Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for PharmacogeneticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.