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Article

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.

Clinical pharmacology and therapeutics - 1 Jun 2021

Bachmann Fabio, Duthaler Urs, Meyer Zu Schwabedissen Henriette E, Puchkov Maxim, Huwyler Jörg, Haschke Manuel, Krähenbühl Stephan

Abstract excerpt

Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4. So far, it is unknown whether metamizole induces additional CYPs and by which mechanism. Therefore, we assessed the activity of 6 different CYPs in 12 healthy male subjects before and after treatment with 3 g of metamizole per day for...

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Identifiers

PMID: 33336382
DOI: 10.1002/cpt.2141
PMCID: PMC8247900

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