Article
Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.
Pharmacogenetics - 1 Jun 1992
Butler M A, Lang N P, Young J F, Caporaso N E, Vineis P, Hayes R B, Teitel C H, Massengill J P, Lawsen M F, Kadlubar F F
Abstract excerpt
The wide variations in urinary bladder and colo-rectal cancer incidence in humans have been attributed in part to metabolic factors associated with exposure to carcinogenic aromatic and heterocyclic amines. Cytochrome P-4501A2 (CYP1A2), which catalyses N-oxidation, and acetyltransferase (NAT2) which catalyses N- and O-acetylation, both appear to be polymorphically distributed in human populations; and slow and...
Topics
- Adult
- Aged
- Arylamine N-Acetyltransferase
- Caffeine
- China
- Colorectal Neoplasms
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme System
- Female
- Genetics, Population
- Humans