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Article

Mesalazine pharmacokinetics and NAT2 phenotype.

European journal of clinical pharmacology - 1 Jan 2009

Lück Hendrik, Kinzig Martina, Jetter Alexander, Fuhr Uwe, Sörgel Fritz

Abstract excerpt

BACKGROUND: Mesalazine undergoes extensive metabolism by N-acetylation. While there is some evidence for an involvement of N-acetyltransferase (NAT) type 1, a potential role of NAT type 2 (NAT2) in vivo has not been tested. METHODS: In two studies in healthy young Caucasians, NAT2 phenotyping was carried out using a caffeine metabolic ratio in urine 4-6 h postdose. In study A, 1,000 mg mesalazine doses were given...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

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Source

Identifiers

PMID: 18704388
DOI: 10.1007/s00228-008-0550-2

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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