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Article

Paracetamol metabolism and related genetic differences.

Drug metabolism reviews - 1 Feb 2011

Zhao Lizi, Pickering Gisèle

Abstract excerpt

Paracetamol (acetaminophen) is a worldwide used analgesic and antipyretic drug. It is metabolised via several metabolic pathways, including glucuronidation, sulfation, oxidation, hydroxylation, and deacetylation: Hepatic and other organ damage may occur, especially in overdose, because of the accumulation of a toxic metabolite. Intersubject and ethnic differences have been reported in paracetamol metabolism...

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Identifiers

PMID: 21108564
DOI: 10.3109/03602532.2010.527984

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