Article
N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism.
Journal of pharmacokinetics and biopharmaceutics - 1 Oct 1996
Spielberg S P
Abstract excerpt
Since the discovery of polymorphic N-acetylation of drugs nearly 40 years ago, great progress has been made in understanding the molecular genetics of acetylation as well as the clinical consequences of being a rapid or slow acetylator. Inborn errors (several different alleles) at the NAT2 locus...
Topics
- Alleles
- Animals
- Anti-Infective Agents
- Arylamine N-Acetyltransferase
- Chromosomes, Human, Pair 8
- Cytochrome P-450 Enzyme System
- Dogs
- Drug Design
- Genetic Variation
- Genotype
- Humans
- Iodide Peroxidase
- Mutagenicity Tests
- Peroxidase
- Pharmacogenetics
- Phenotype
- Polymorphism, Genetic
- Sulfonamides