Article
Phosphorylation of Nox1 regulates association with NoxA1 activation domain.
Circulation research - 7 Nov 2014
Streeter Jennifer, Schickling Brandon M, Jiang Shuxia, Stanic Bojana, Thiel William H, Gakhar Lokesh, Houtman Jon C D, Miller Francis J
Abstract excerpt
RATIONALE: Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease. Selective targeting of Nox1 is an attractive potential therapy, but requires a better understanding of the molecular modifications controlling its activation. OBJECTIVE: To determine whether posttranslational modifications of Nox1 regulate its activity in vascular cells. METHODS AND RESULTS:...
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